NETosis 2 The Excitement Continues

Download or Read online NETosis 2 The Excitement Continues full in PDF, ePub and kindle. This book written by Mariana J. Kaplan and published by Frontiers Media SA which was released on 28 December 2017 with total pages null. We cannot guarantee that NETosis 2 The Excitement Continues book is available in the library, click Get Book button to download or read online books. Join over 650.000 happy Readers and READ as many books as you like.

NETosis 2  The Excitement Continues
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Publisher : Frontiers Media SA
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ISBN : 9782889453795
Pages : null pages
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NETosis, a form of cell death that manifests by the release of decondensed chromatin to the extracellular space, provides valuable insights into mechanisms and consequences of cellular demise. Because extracellular chromatin can immobilize microbes, the extended nucleohistone network was called a neutrophil extracellular trap (NET), and the process of chromatin release was proposed to serve an innate immune defense function. Extracellular chromatin NETs were initially observed in studies of neutrophils and are most prominent in these types of granulocytes. Subsequent studies showed that other granulocytes and, in a limited way, other cells of the innate immune response may also release nuclear chromatin following certain kinds of stimulation. Variations of NETosis were noted with cells that remain temporarily motile after the release of chromatin. Numerous stimuli for NETosis were discovered, including bacterial breakdown products, inflammatory stimuli, particulate matter, certain crystals, immune complexes and activated thrombocytes. Fundamental explorations into the mechanisms of NETosis observed that neutrophil enzyme activity (PAD4, neutrophil elastase, proteinase 3 and myeloperoxidase) and signal transduction pathways contribute to the regulation of NETosis. Histones in NET chromatin become modified by peptidylarginine deiminase 4 (PAD4) and cleaved at specific sites by proteases, leading to extensive chromatin externalization. In addition, NETs serve for attachment of bactericidal enzymes including myeloperoxidase, leukocyte proteases, and the cathelicidin LL-37. NETs are decorated with proteases and may thus contribute to tissue destruction. However, the attachment of these enzymes to NET-associated supramolecular structures restricts systemic spread of the proteolytic activity. While the benefit of NETs in an infection appears obvious, NETs also participate as key protagonists in various pathologic states. Therefore, it is essential for NETs to be efficiently cleared; otherwise digestive enzymes may gain access to tissues where inflammation takes place. Persistent NET exposure at sites of inflammation may lead to a further complication: NET antigens may provoke acquired immune responses and, over time, could initiate autoimmune reactions, serve as antigen for nuclear autoantibodies and foster DNA immune complex-related inflammation. Neutrophil products and deiminated proteins comprise an important group of autoantigens in musculoskeletal disorders. Aberrant NET synthesis and/or clearance are often associated with inflammatory and autoimmune conditions. Recent evidence also implicates aberrant NET formation in the development of endothelial damage, atherosclerosis and thrombosis. Intravital microscopy provides evidence for conditions that induce NETosis in vivo. Furthermore, NETs can easily be detected in synovial fluid and tissue sections of patients with arthritis and gout. NETosis is thus of interest to researchers who investigate innate immune responses, host-pathogen interactions, chronic inflammatory disorders, cell and vascular biology, biochemistry, and autoimmunity. As we enter the second decade of research on NETosis, it is useful and timely to review the mechanisms and pathways of NET formation, their role in bacterial and fungal defense and their importance as inducers of autoimmune responses.

NETosis 2  The Excitement Continues

NETosis, a form of cell death that manifests by the release of decondensed chromatin to the extracellular space, provides valuable insights into mechanisms and consequences of cellular demise. Because extracellular chromatin can immobilize microbes, the extended nucleohistone network was called a neutrophil extracellular trap (NET), and the process of chromatin

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NETosis

NETosis: Immunity, Pathogenesis and Therapeutics takes a focused approach to the clinical aspects of NETosis and drug development, bringing critical findings. Chapters introduce NETosis, consider mechanisms and antimicrobial strategies regulating NETosis, examine NETosis in neonates, explore the role of NETosis in autoimmunity, delve into NETosis and other diseases, and present

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NETosis  At the Intersection of Cell Biology  Microbiology  and Immunology

NETosis is a unique form of cell death that is characterized by the release of decondensed chromatin and granular contents to the extracellular space. The initial observation of NETosis placed the process within the context of the innate immune response to infections. Neutrophils, the most numerous leukocytes that arrive quickly

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Canine Neutrophils and Platelets in Sepsis

Sepsis remains one of the leading causes of death due to critical illness in human and veterinary medicine. Neutrophils release neutrophil extracellular traps (NETs) composed of cell-free DNA (cfDNA) decorated with histones and antimicrobial proteins. Platelets function as a primary effector cell of hemostasis, serving as innate immune cells in

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Promyelocyte HL 60 Cell line Demonstrates the Involvement of NETosis Related Proteins in Neutrophil Nuclear Morphology Dynamics

Neutrophils are characterized by a unique nuclear morphology, where the nucleus possesses a segmented multi-lobed form. During inflammation, neutrophils become activated and utilize their anti-microbial abilities. Neutrophil activation and extracellular trap formation are associated with the cell undergoing a change in nuclear morphology via delobing of the nucleus. While much

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The Role of Galectin 3 mediated NETosis in Systemic Lupus Erythematosus

Download or read online The Role of Galectin 3 mediated NETosis in Systemic Lupus Erythematosus written by 陳璟儀, published by Unknown which was released on 2017. Get The Role of Galectin 3 mediated NETosis in Systemic Lupus Erythematosus Books now! Available in PDF, ePub and Kindle.

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Physical Phenotyping of Neutrophil NETosis Using Fluorescence Imaging Deformability Cytometry

The cell mechanical phenotype is a useful measure to understand cell identity and state. Cell mechanical properties such as deformability can provide an understanding of cellular processes or intracellular composition without direct labeling. The cell nucleus is a significant component of the cell and it is useful to understand how

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On the Role of Neutrophils and NETosis in Acute Pancreatitis

Download or read online On the Role of Neutrophils and NETosis in Acute Pancreatitis written by Anonim, published by Unknown which was released on 2020. Get On the Role of Neutrophils and NETosis in Acute Pancreatitis Books now! Available in PDF, ePub and Kindle.

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NEC is a NETs dependent process and markers of NETosis are predictive of NEC in mice and humans

Download or read online NEC is a NETs dependent process and markers of NETosis are predictive of NEC in mice and humans written by Deirdre Kathleen Vincent, published by Unknown which was released on 2020. Get NEC is a NETs dependent process and markers of NETosis are predictive of NEC in

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Role of Neutrophils in Disease Pathogenesis

This book highlights the important role of neutrophils in health as well as in the pathogenesis of various diseases. Section 1 provides a general background information regarding the mechanisms and various triggers of neutrophil extracellular traps (NETs) formation and their role in various infectious and noninfectious diseases (such as postinjury inflammation).

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Characterization of NETosis derived Effector Mechanisms Against Besnoitia Besnoiti in Cattle

Download or read online Characterization of NETosis derived Effector Mechanisms Against Besnoitia Besnoiti in Cattle written by Ershun Zhou, published by Unknown which was released on 2019. Get Characterization of NETosis derived Effector Mechanisms Against Besnoitia Besnoiti in Cattle Books now! Available in PDF, ePub and Kindle.

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Damage Associated Molecular Patterns in Human Diseases

This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of

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NETosis derived Effector Mechanisms Against Neospora Caninum and New Insights of Seroprevalances in Caprine and Canine Neosporosis

Download or read online NETosis derived Effector Mechanisms Against Neospora Caninum and New Insights of Seroprevalances in Caprine and Canine Neosporosis written by Rodolfo Villagra-Blanco, published by Unknown which was released on 2018. Get NETosis derived Effector Mechanisms Against Neospora Caninum and New Insights of Seroprevalances in Caprine and Canine Neosporosis

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NLRP3 Inflammasome  Regulatory Mechanisms  Role in Health and Disease and Therapeutic Potential

Download or read online NLRP3 Inflammasome Regulatory Mechanisms Role in Health and Disease and Therapeutic Potential written by Kuo-Feng Hua,Oleg Chernikov,Ann Chen,Jong-Seok Moon, published by Frontiers Media SA which was released on 2021-11-08. Get NLRP3 Inflammasome Regulatory Mechanisms Role in Health and Disease and Therapeutic Potential

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Skin Autoimmunity

Download or read online Skin Autoimmunity written by Ralf J. Ludwig,Katja Bieber,Christian David Sadik,Michael P. Schön,Gang Wang,Karin Loser, published by Frontiers Media SA which was released on 2021-05-25. Get Skin Autoimmunity Books now! Available in PDF, ePub and Kindle.

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