Clinical Studies and Therapies in Parkinson s Disease

Download or Read online Clinical Studies and Therapies in Parkinson s Disease full in PDF, ePub and kindle. This book written by Juan Segura-Aguilar and published by Academic Press which was released on 12 June 2021 with total pages 306. We cannot guarantee that Clinical Studies and Therapies in Parkinson s Disease book is available in the library, click Get Book button to download or read online books. Join over 650.000 happy Readers and READ as many books as you like.

Clinical Studies and Therapies in Parkinson s Disease
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Publisher : Academic Press
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ISBN : 9780128221587
Pages : 306 pages
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Download or Read Online Clinical Studies and Therapies in Parkinson s Disease in PDF, Epub and Kindle

More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson’s disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson’s disease, but these efforts have failed when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease. Clinical Studies and Therapies in Parkinson’s Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed. Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the book’s discussion of these newer models, their benefits, and the need for their implementation. This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine. Reviews Parkinson's disease classification, pharmacological therapies, and nonmotor and motor symptoms Analyzes preclinical models of Parkinson’s disease therapies based on exogenous neurotoxins and why they have failed Reviews genetic preclinical models based on genetic mutations and endogenous neurotoxins Proposes a more physiological model directly related to the metabolism of dopaminergic neurons Provides the basic concepts and mechanisms of dopamine metabolism

Clinical Studies and Therapies in Parkinson s Disease

More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson’s disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for

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Towards New Therapies for Parkinson s Disease

Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in

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Therapeutics of Parkinson s Disease and Other Movement Disorders

Provides a comprehensive update on therapies for Parkinson’s disease and other movement disorders Describes the basic mechanisms of neurodegeneration, pharmacologic interventions for motor and non-motor symptoms, and surgical management Features summary tables and algorithms that serve as a quick reference guide for practical treatment decisions The expert guidance of

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Parkinson s Disease  Current and Future Therapeutics and Clinical Trials

This book emphasizes treatment options for Parkinson's disease, providing the necessary clinical and scientific basis for the foundations of solid therapeutics.

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Parkinson s Disease

Download or read online Parkinson s Disease written by National Collaborating Centre for Chronic Conditions (Great Britain), published by Royal College of Physicians which was released on 2006. Get Parkinson s Disease Books now! Available in PDF, ePub and Kindle.

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Leucine Rich Repeat Kinase 2  LRRK2

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry,

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Levodopa Induced Dyskinesia in Parkinson s Disease

This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from ‘bench to bedside’. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The

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Principles of Treatment in Parkinson s Disease

This succinct volume offers an up-to-date review and comparison of the treatment options available for Parkinson's disease, and provides evidence-based recommendations on appropriate treatments for specific cases. Offers expert guidance on the best treatment options from authorities in the field. Delivers expert guidance on drug therapies, physical therapies, and surgical

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Non Motor Symptoms of Parkinson s Disease

Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for

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Etiology of Parkinson s Disease

This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.

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Diagnosis and Treatment of Parkinson   s Disease     State of the Art

Expert clinicians and basic scientists with a special interest in Parkinson’s disease review the current state of science and clinical therapeutics of the disease. Therefore these articles represent an authorative review of the current state of knowledge regarding preclinical course and symptomatology, subtypes with their impact on the pathology,

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Parkinson s Disease

Parkinson’s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue

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Mucuna versus Parkinson  treatment with natural levodopa

“Mucuna pruriens” is a bean that grows in the tropics. It is very rich in natural levodopa that is better tolerated and more potent than the synthetic levodopa in Sinemet or Stalevo. Two prestigious neurologists have patented extracts of mucuna seeds as a treatment for Parkinson's. Meanwhile, patients have recorded

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Challenges in Parkinson s Disease

Download or read online Challenges in Parkinson s Disease written by Anonim, published by Unknown which was released on 2016. Get Challenges in Parkinson s Disease Books now! Available in PDF, ePub and Kindle.

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Fast Facts  Psychosis in Parkinson s Disease

Psychosis affects nearly 50% of patients with Parkinson’s disease (PD). It is a major therapeutic challenge, as a balance needs to be found between the PD medications that can exacerbate psychotic symptoms and the antipsychotics that may worsen motor function. Focusing on the most common side effects of PD medications,

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